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Chloramphenicol is known to cause bone marrow suppression, especially when serum concentrations exceed 25 mcg/ml

Theyre adjusted based on your health and personal life

A common protocol for patients with a B12 deficiency may be 1,000 mcg daily for one week, then the same dosage once weekly, and then the same dosage once per month after the deficiency has been addressed

To unpack why the mechanism matters for dosing: NNMT sits at a metabolic crossroads

Advertisement If you have chronic low B12 levels or have underlying health conditions that cause the deficiency, you may need to take B12 for the rest of your life (or for as long as you have the underlying condition)

In a 23-week randomized clinical trial in humans, individuals taking AOD-9604 at 1 mg daily had an average of 2.8 kg weight reduction compared to a 0.8 kg weight reduction in those taking a placebo