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Recent studies suggest that PS-NPs disrupt glutamate cycling by suppressing astrocytic EAAT2, resulting in aberrant synaptic transmission and excitotoxic neuronal damage

Furthermore, NM-rich neurons exhibit accumulation of immunoglobulin G and expression of major histocompatibility complex class I antigens, directly correlated with neuronal loss

The insulin-like growth factor 1 (IGF-1) is a hormone widely expressed throughout the body that plays a crucial role in promoting anabolic processes

Phenolic compounds are natural antioxidants and bind to the cellulose matrixes of the plant cell walls [212]

Several risk factors including age, hypertension, ischemic heart disease, diabetes, and chronic respiratory disease (Khanfar and Al Qaroot, 2020) increase the fatality rate (Ruan et al., 2020

Consistently, SIRT1 suppresses the high expression of proinflammatory factors, including IL-6, IL-8, and TNF-, and alleviates intestinal epithelia barrier dysfunction by hindering the expression and activity of HIF1 in necrotizing enterocolitis (142)