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2.6 Areas to be investigated to expand research in the field of CD38 2.6.1 Fate of unbound therapeutic antibody One proposal is the selection of therapeutic antibodies that show negligible reactivity with red blood cells (RBC) and platelets, which are reported to express CD38 at a cell surface density too low to trigger lysis

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Its proposed mechanism is to stimulate lipolysis (the breakdown of stored fat) and to inhibit lipogenesis (the formation of new fat), apparently through -adrenergic-related pathways, while unlike full-length GH not raising IGF-1 and not impairing glucose tolerance [1] [5]

Clinicians are urged to exercise caution and to proactively counsel patients who may be using these products without disclosure

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