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Moreover, MG generates advanced glycation end-products [185] which can reduce the activities of important defense enzymes such as GSTs [186] and cytosolic ascorbate peroxidase [187] by lowering their affinity for their respective substrates

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In addition, evidence suggests that changes in glutathione (GSH) homeostasis and detoxification may contribute directly or indirectly to the progression of liver disease induced by the damage from alcohol consumption [5, 6]

[PubMed] [Google Scholar] [68].Hidalgo J, Garvey JS, Armario A

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