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For example, lysosomes can be an effective trigger for nanodrug delivery systems based on their low pH (4.55) properties, 249 groups such as disulfide, hydrazone, and dinitroimidazole are highly reactive to acidic environments and can be degraded to facilitate precise drug release in the lysosomal environment, thereby allowing the drug to passively target lysosomes

The weakened interaction observed in GR-deficient strains indicates a reduced capacity to evade or resist host immune responses, which is important for establishing and maintaining infections

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A dietary intervention with reduction of starch and sucrose leads to reduced gastrointestinal and extra-intestinal symptoms in IBS patients

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Additionally, other defence related genes coding for protease inhibitor genes, R-genes or some chitinases were down-regulated in SL (Fig