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P values were adjusted for multiple testing using the Bonferroni method (adjusting for the number of cell populations the number of modules)

For instance, in preclinical models, long-term ketamine exposure increases the expression of GABA receptor subunits in the prefrontal cortex while simultaneously reducing glutamate receptor subunits, impairing synaptic signaling and cognitive function ( Ketamine also downregulates brain-derived neurotrophic factor, particularly in the hippocampus, exacerbating deficits in synaptic plasticity and cognitive functions

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COVID arm is a local reaction by your immune system, meaning it occurs around the injection site
