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Glutathione (GSH), composed of gamma-glutamylcysteinylglycine, stands as the most abundant intracellular thiol in aerobic cells, and its synthesis by GSS is essential for diverse cellular processes

SLC25A12 and SLC25A13 transport activity are irreversible due to being driven by the proton-motive force across the IMM (Borst, 2020)

Other PTMs of NRF2 In addition to the above-mentioned PTMs, NRF2 undergoes a variety of other PTMs that also play important roles in regulating its stability, activity, and cellular localization