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GCEE may react directly with ROS due to the cysteine residue and/or increase GSH, which can protect against ROS and nucleophilic compounds

PMID 23417317 Zdrada-Nowak, J., Surgiel-Gemza, A., & Szatkowska, M

Britton, M

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Topically administering a stable emulsion of 2% Muscat Hamburg grape seed extract in a mixture of water and oil on the cheek skin of male Pakistani volunteers for a duration of 8 weeks led to favorable improvements in facial skin elasticity, sebum content, and melanin levels [139]