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ER- positive/ HER2 negative In ER-positive/HER2-negative breast cancer, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mutational status correlates with high glucose uptake and glycolysis dependence [34]

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in vitro and in vivo studies showed that vitamin K2 (menaquinone-4) and vitamin K3 (menadione) have anticancer effects against triple-negative breast cancer (TNBC) and Her2+ breast cancer cells (57)