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Its involvement extends from early embryogenesis through to postnatal brain maturation and continues to influence cognitive and neurological function throughout life [14, 16, 17]

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Furthermore, combining BPTES with chemotherapeutic drugs resensitizes drug-resistant cancer cell lines to chemotherapy, regardless of their glutamine dependence status (Masamha and LaFontaine, 2018)

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In this five-year update of the ECHELON-2 trial, the frontline treatment of patients with PTCL using A + CHP continues to provide clinically meaningful improvements in PFS and OS compared to CHOP, with a manageable safety profile, including the continued resolution or improvement of peripheral neuropathy [226]