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IGF-1/IGF-1R induces differentiation rather than proliferation when the cells do not express or underexpress insulin receptor substrate-1 (IRS-1), a docking protein for both IGF-1R and the insulin receptor that is known to send a mitogenic, anti-apoptotic and anti-differentiation signal 35,36
The HR N 1s had been well fitted at 399.9 and 400.6 eV according to pyrrolic N (70.14%) and amino (29.86%) (Supplementary Figure S2)
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