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Insulin-like growth factor-1 (IGF-1) is an anabolic peptide hormone produced by the liver, which exerts multifaceted vasoprotective and anti-geronic effects [1, 10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36]

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