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In this regard, our in vitro experiments evidenced that under GSH depletion the increased NO availability induced S-nitrosylation of nuclear resident p53 at different cysteine residues, among which the Cys124 was essential for the induction of p53-mediated antioxidant response in C2C12 myoblasts

For instance, its been demonstrated that zinc increases the expression of important proteins involved in oxidative stress management, like GSH S-transferases, which are essential for detoxifying ROS produced under stressful circumstances [76]

[Google Scholar] 3.Ferguson TS, Tulloch-Reid MK, Wilks RJ

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