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doi:10.1016/j.mce.2017.01.038

In response to various PAMPs and DAMPs, NLRP3 oligomerizes with the adapter protein ASC to form a high molecular weight complex that recruits and cleaves pro-caspase-1, activating it and driving the maturation of IL-1 and IL-18, GSDMD cleavage, and pyroptosis

13 Inflammation mediated by immune cells was enhanced in degenerated IVDs, and degradation products of these cells, such as IL-4, IL-6, IL-12, IFN-, and MMPs, led to a reduction in NP cell number and deterioration of the IVD microenvironment

10.1101/cshperspect.a022293

Glutathione is an essential molecule required for detoxification

Tarquino, D.O./Center for Rare Neurological Diseases, April 5, 2022
