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Subsequently, experiments showed that LDL binding to the LDL receptor at specific sites on the membranes, called clathrin-coated pits, triggered internalization of the receptor, followed by lysosomal hydrolysis to free the cholesterol from the LDL particle

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How these proteins coordinate polymerization of new glycan strands with their crosslinking to the existing peptidoglycan meshwork is unclear

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CGI-S, Clinical Global Impression of Severity

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This does not indicate degradation

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We generated all-in-one constructs for GFP knock-in into the GLABRA2 ( GL2 ) locus, utilizing these promoters to drive Cas9 expression and an sgRNA known to efficiently generate site-specific DSB in GL2 53 (Supplementary Fig

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