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Loss-of-function but not gain-of-function properties of mutant TP53 are critical for the proliferation, survival, and metastasis of a broad range of cancer cells

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DOI: 10.15825/1995-1191-2014-2-46-51 61

While the cause of POI is unknown in most cases, it can result from chemotherapy or radiation treatment, autoimmune disorders, or genetics

If the next scheduled dose is almost due, just skip the one you missed and carry on as usual never stack two doses to catch up