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While semaglutide does not directly cause leg cramps through its pharmacological mechanism, several indirect pathways related to its effects and the physiological changes during treatment may potentially contribute to muscle cramping in susceptible individuals

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Research from Stanford University Medical Center found that intermittent GH pulses upregulated IGF-1 mRNA expression 2.8-fold more effectively than continuous infusion at equivalent AUC (area under curve)

Microglial activation in stroke: therapeutic targets

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doi: 10.1016/S0140-6736(24)01940-8 30 BarnawiH.QanashH.AldarhamiA.AlsaifG.AlharbiB.AlmashjaryM