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[59] reported that the administration of carnitine alongside physical exercise stimulates the activity of pyruvate dehydrogenase, limited by the availability of NAD+

Rosser EC, Piper CJM, Matei DE, Blair PA, Rendeiro AF, Orford M, et al

(PubMed) Salminen S, Collado MC, Endo A, et al
"Propionyl-L-carnitine for intermittent claudication." Cureus 2021;13:e17592

first proposed that TMAO may be a target to treat arrhythmia (125)

Management strategies for symptomatic and asymptomatic PAD include maximal risk factor modification and conservative treatment with exercise
