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used trypsin digestion to show that only a central domain of a lysine-rich histone H1 from calf thymus (residues 37120) is in a folded conformation, whereas N- and C-terminal regions (residues 136 and 121213, respectively) are very accessible in chromatin and therefore likely not in a compact, folded conformation ( Grzelczak et al

Typical cycle: 812 weeks on, followed by 48 weeks off

Elevated blood concentration of methylmalonic acid is a specific clinical indicator of vitamin B 12 deficiency

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