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472 Interestingly, compound A20, identified through sEH-targeted screening, alleviates neuropathic pain in rats in a dose-dependent manner, outperforming gabapentin and the sEH inhibitor EC5026

In contrast to findings in the APPROACH and COMPASS trials, volanesorsen or olezarsen ASO treatment did not significantly alter plasma LDL-cholesterol concentration in patients with mild-to-moderate HTG [81, 88]

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Most notable, there were only few eligible RCTs included in this meta-analysis and most of them had a relatively modest number of participants