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Associations have been found between Hashimoto's disease and the following HLA alleles: [19] [20] [21] C*07:04 DQB1*03:03 DRB1 DRB1*04:10 ME/CFS and Hashimoto's genetics In a large 2020 study, CFS patients with Human Leukocyte Antigen (HLA) risk alleles ( C*07:04 and DQB1*03:03 ) were found to share the following autoimmune diseases, ordered by frequency: [21] Hashimoto's thyroiditis Psoriasis Rheumatoid arthritis Alopecia areata Crohns disease or ulcerative colitis Diagnosis Hashimoto's thyroiditis is usually diagnosed based on multiple examinations, often beginning with hypothyroid symptom evaluation