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This modified peptide that lacked Tyr at residue 10 would be predicted not to lead to cell death or protein oxidation of neuronal cultures or be able to activate the nitrone spin trap to form the EPR-measurable nitroxide free radical if the Tyr residue of A42 was critical to these effects of A42

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Effect of glycine propionyl-L-carnitine on aerobic and anaerobic exercise performance

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Biochemistry 23 , 64226426 (1984)