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As single-cell and multi-omics technologies continue to mature, researchers will increasingly be able to profile DNA methylation, histone modifications, chromatin accessibility, and gene expression within the same cell, thereby generating a more accurate picture of epigenetic changes associated with depression and addiction 186,187

alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans

Jain N, Thompson PA, Ferrajoli A, Burger JA, Borthakur G , Takahashi K, Bose P, Estrov Z, Jabbour EJ, Konopleva M, Alvarado Y, Kadia T, Yilmaz M, DiNardo CD, Ohanian M, Cortes JE, Kanagal-Shamanna R, Patel K, Garg N, Wang X, Fru N, Cruz N, Gandhi V, Plunkett W, Kantarjian HM, Keating MJ, Wierda WG

[DOI] [PubMed] [Google Scholar] 117.Woods J.S., Calas C.A., Aicher L.D

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By emitting a do not eat me signal, CD47 inhibits the phagocytic capacity of microglia toward both ferroptotic neurons and A plaques, leading to an immune-tolerant state
