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Memorial Sloan-Kettering Cancer Center Annual Report, 2013
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10.1049/enb.2019.0001

Central nervous system rather than immune cell-derived BDNF mediates axonal protective effects early in autoimmune demyelination
The 7-hour interval between doses for regimen E was chosen based on the evaluation of the PK/PD data from regimens B and C to give the optimal rise in IGF-1 concentrations over a 24-hour period

Cook RS, Jacobsen KM, Wofford AM, DeRyckere D, Stanford J, Prieto AL et al
