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Melanocortin Receptor Subtype Activity MT-2 engages melanocortin receptors across four subtypes with varying affinity: MC1R (melanocytes eumelanin synthesis), MC3R (hypothalamus and peripheral tissues energy homeostasis), MC4R (hypothalamus and limbic system appetite, arousal, autonomic function), and MC5R (exocrine glands secretory functions)

Su et al

While the compounds structure is undisclosed, it is described to have potent activity on hMC4R in a functional cAMP assay (EC 50 = 2 nM, E max = 95%), inactivity on hMC3R, and reduced potency on hMC1R (136)

1), S12

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