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Additionally, metformin has been shown to improve sputum culture conversion and lower the relapse rate of patients with TB-DM [122]

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The key is spacing treatments at least one week apart to avoid potential issues like electrolyte imbalances or vitamin overload

This provides an explanation for the involvement of neurexins proteins in the mechanism of sustained antidepressant effect mediated by BDNF signaling, but recent studies have not clarified their relative upstream and downstream relationship to BDNF signaling, and the mechanism of this regulation at the protein level awaits further clarification

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