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However, they can cause dryness, itching, and burning sensations on the skin

This review focuses on six commonly abused drugs (Table 1), classified based on their pharmacological and neurotoxic profiles: Psychostimulants: Methamphetamine (METH), cocaine and synthetic cathinones (bath salts) primarily act on monoaminergic systems, leading to disruptions in dopamine, serotonin, and norepinephrine signaling ( 2 O predominantly affect glutamatergic transmission by antagonizing NMDA receptors (NMDARs), causing excitotoxicity, mitochondrial dysfunction, and neuronal apoptosis

Mitochondrial dysfunction Mitochondria serve as the primary intracellular source of ROS during normal aging

and UPAR (Grant numbers: 12S169 and 12S291) to KE-T

Goritz, C., Dias, D