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Biomedicines (2022) 10:948

Knudgaard MH, Andreasen TH, Ravnborg N, et al

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Expression of a dominant negative form of SREBP-1c blocked insulin-stimulated Gck expression in rat primary hepatocytes, whereas expression of an active form of SREBP-1c increased expression of Gck independently of insulin stimulation (94)

Furthermore, elevated levels of liver enzymes like alanine transaminase (ALT) and aspartate transaminase (AST) are observed in both PCD and fatty liver disease, reecting the underlying liver damage
