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In the presence of free transition metal ions, ascorbate can generate OH, leading to the initiation of lipid peroxidation

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To this end, multiple studies reported matrix metalloprotease- and ADAM-dependent cleavage sites at Arg31-Leu32 and Pro52-Leu53 that were inhibited by O-glycosylation at Ser 37 /Ser 41 (Goth et al., 2017

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Blood pressure and heart rate remained stable

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