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Unlike other G-protein-coupled receptors, which do not have introns, in this gene there is a coding sequence interrupted by several introns

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[DOI] [PubMed] [Google Scholar] 87.Zerwekh JE, Homan R, Tindall R, Pak CY

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For instance hippuric acid enhances M1 polarization through the TLR/MyD88 pathway ( Figure 1 M2 polarization is primarily driven by IL-4 and IL-13 through activation of the STAT6 signaling pathway and induces the expression of anti-inflammatory genes such as Arg1 ( Macrophage polarization involves multilayered crosstalk among signaling pathways

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