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Abortive therapy Evidence for treatment in CHS is limited to case series and small clinical trials supporting the use of topical capsaicin, benzodiazepines, haloperidol, promethazine, olanzapine, and ondansetron, among others, for acute vomiting attacks.5,46,124126 Topical Capsaicin Topical capsaicin cream has shown short-term success as an adjunctive therapy in patients suffering from CHS.39 Topical capsaicin (0.1%) cream may improve symptoms by activation of TRPV1 receptors, but data are limited

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