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aeruginosa (68.7%), Methicilline Sensitive Staphylococcus Aureus (MSSA) (31.2%), and Methicilline Resistant Staphylococcus Aureus (MRSA) (12.5%) ( N-acetylcysteine (NAC) benefits cystic fibrosis by mitigating oxidative stress and inflammation through antioxidant, anti-inflammatory, and anti-LPS mechanisms, partly via modulation of neurokinin A and IL-6
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N Eng J Med 354:229240 Equi A, Balfour-Lynn IM, Bush A, Rosenthal M (2002) Long term azitromycin in children with cystic fibrosis: a randomized, placebo controlled cross-over trial
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In summary, the three antioxidant systems Xc -GSH-GPX4, FSP1-CoQ 10 -NAD(P)H, and GCH1-BH 4 can scavenge lipid peroxides during ferroptosis
