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Thus, we posit that the dose of APR-246 needed to sufficiently restore wildtype function and overcome dominant negative effects of remaining p53 mutants is the major limitation in these studies

These abnormally large red blood cells, known as megaloblasts, simply can't carry oxygen as efficiently as healthy, normal-sized ones

References Alam MS, C

This contrasting finding is curious because our R801 strain derivate from the R6 strain

Molecular and functional analyses of motor neurons generated from human cord-blood-derived induced pluripotent stem cells
