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Curcumin exerts dose-dependent inhibition of COX-2 mRNA and protein expression across various experimental inflammation models, mainly through the suppression of transcription factors NF-B and activator protein 1 (AP-1)

Studies suggest that regional anesthesia, such as paravertebral and epidural blocks may preserve NK cell function, improve Th1/Th2 balance and reduce the need for opioids

Combination-therapy models: Evaluating interactions with GLP-1 receptor agonists (e.g., semaglutide) to study additive or complementary effects on appetite and metabolism
