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Cramps of pain associated with B12 deficiency-related neuropathy can happen at any time of day - or just at night. Most conditions that cause leg pain or numbness improve with rest, but symptoms that persist could be signalling an underlying deficiency

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What ingredients in B12 supplements might cause digestive upset

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[54] In addition, elevated methylmalonic acid levels may also be related to metabolic disorders such as methylmalonic acidemia

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