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Acknowledgments This work was supported by a Discovery Project Grant from the Australian Research Council (ARC

P53 protein levels fluctuate across the day, driven by circadian control of MDM2 (the E3 ubiquitin ligase that targets p53 for degradation)

P.et al (2022)

Although these two aldehydes have been extensively studied, and excessive accumulation of 4-HNE has been shown to promote apoptosis and necrosis, their role in ferroptosis is unclear

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To this end, recent work by Jin and colleagues explored the use of a Tat - syn-degron peptide to bind alpha-synuclein and induce its proteasomal degradation specifically