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Small fibers are preferentially impaired in PDPN

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Similarly, a clinical study involving patients with coronary artery disease demonstrated that 12 weeks of L-carnitine supplementation resulted in reduced malondialdehyde levels, increased circulating L-carnitine concentrations, and enhanced activities of catalase and glutathione peroxidase enzymes compared to the placebo group

Fouchier, S

Glycogen-sparing is one of the most practically significant effects of adequate carnitine during endurance activities preserving muscle glycogen extends the time to glycogen-depletion-induced fatigue, directly improving endurance duration and quality.

Furthermore, dynamic PDU has a crucial role in the differential diagnosis between psychogenic and the most common form of organic ED, namely vasculogenic ED, in patients of different ages [35]