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Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes

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Colostrum levels were 778 and 320 pmol/L (1,054 and 434 ng/L), respectively, and at 3 months postpartum were 235 and 170 pmol/L (318 and 230 ng/L), respectively.[25] Based on the 65 pmol/L (88 ng/L) difference in median milk levels reported at 3 months, exclusively breastfed infants would receive an extra 0.013 mcg/kg daily of vitamin B 12 from maternal 250 mcg once daily oral supplementation