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People lacking enough Vitamin B12 in their bodies can suffer from a wide range of symptoms, many of which can negatively impact their quality of life

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& Okabe, S

Mol Cell Biochem

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Under pathological conditions, FUNDC1 persists in a phosphorylated state that specifically impedes its molecular interaction with the autophagosomal marker protein LC3-II, consequently suppressing mitophagy initiation and ultimately inducing neuronal dysfunction ( Mitochondrial fragmentation has also been demonstrated in AD patients and model animals