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97,98,99,100,101,102,103,104,105 TNF- suppresses the production of ECM, including collagen, aggrecan, and fibromodulin, but increases the expression of MMP-3, -9, and -13 and NGF

Conclusion: This consensus underscores the role of NAC in chronic respiratory diseases beyond its mucolytic properties and reiterates that NACs antioxidant, anti-inflammatory, immunomodulatory and anti-biofilm properties provide significant clinical utility

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[DOI] [Google Scholar] 221.Cirri M., Mennini N., Maestrelli F., Mura P., Ghelardini C., Mannelli L

A competing ligand or a change in local redox state can cause the peptide to release copper