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Remarkably, this rate has seen little improvement over the past three decades [1, 2]

10.1101/gad.947102 23 BodeA

Furthermore, macrophage polarization, caused by hyperglycemia and oxidative stress, is the major reason for delayed wound healing (Jiang et al., 2019)

In constraint-based modeling, cellular metabolism is represented as a network of reactions with constraints based on known biochemical principles to predict metabolic fluxes and identify active pathways

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