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Kovalyova Y, Bak DW, Gordon EM, Fung C, Shuman JHB, Cover TL, et al
doi: 10.1016/j.cardiores.2007.05.026 168 BirSCKolluruGKMcCarthyPShenXPardueSPattilloCBet al
It is noteworthy that cystine starvation has been observed to induce -glutamyl-peptide accumulation via the NFE2-like BZIP transcription factor 2 (NRF2)-glutamate-cysteine ligase catalytic subunit (GCLC) axis, thereby preventing ferroptosis in a GSH-independent manner in non-small cell lung cancer (NSCLC) cells [44]
It's about aligning the compound's mechanism with your experimental hypothesis
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J Hepatol 78:989997
