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Last but not least, the real-life ICU scenario in which patients with ALI/ARDS were treated with a combination of pharmacological and non-pharmacological interventions is difficult to replicate in mouse models, and endpoint assessment in experimental models does not accurately reflect the disease progression in human ALI/ARDS [154]

PINK1-knockout (KO) astrocytes exhibit decreased mitochondrial mass, decreased membrane potential, decreased glucose uptake, and increased intracellular ROS levels [9]

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Whitwell JL, Tosakulwong N, Weigand SD, Graff-Radford J, Ertekin-Taner N, Machulda MM, Duffy JR, Schwarz CG, Senjem ML, Jack CR, Lowe VJ, Josephs KA