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In contrast, COX-1 is normally active in many tissues, where it has roles unrelated to inflammation (e.g., clotting function in blood platelets, mucus production from cells lining the GI tract) (Toussaint 2010

Cytotoxic T lymphocytes (CD8+) are the main immune cells involved in the pathogenesis of the disease, primarily in initial or active phases

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however, the determination and in situ quantification of endogenously produced glutathione remains a major challenge

Thermal Shift assays Tryptophan fluorescence measurements were carried out using Prometheus Panta (NanoTemper Technologies)

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