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Very different from innate immune activation

Sun et al., 2019)

Gene Regulation: Affecting hundreds of human genes associated with immune function, repair pathways, and proteostasis

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RTqPCR revealed expression of the hepatic markers A1AT , AFP, ALB , and ASGR1 as well as genes enriched in the liver such as APOA2 , TDO2 and TTR and xenobiotic metabolism, cytochrome P450 ( CYP) 3A4 and CYP3A7 (Supplementary Fig

This study demonstrated that these NPs compromised BBB integrity, decreased cerebral blood flow, and induced brain edema, neuronal damage, glial activation, upregulation of heat shock proteins, and myelin degeneration