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The authors even went so far as to call this action resetting genes to promote normal functioning

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The in vitro metabolism of chloroform by male, but not female, renal slices is consistent with reduced susceptibility of female mice to in vivo chloroform nephrotoxicity (Smith et al., 1983

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Other than designing peptides that competitively bind to the CatB/L protease, peptides that inhibit endosomal acidification can also be used to inhibit the activity of CatB/L and other host cell proteases that is pH-dependent [93, 94]