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NRF2 controls many of the enzymes that participate in glutathione synthesis and metabolism, including the catalytic and regulatory subunits of glutamate-cysteine ligase (GCLC/GCLM), glutathione synthase (GSS) and the subunit of the cystine/glutamate transporter xCT (SLC7A11), all of which are required for glutathione synthesis (Kwak et al., 2002

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Am J Psychiatry 158:18181826 Dringen R (2000) Metabolism and functions of glutathione in brain

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