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Curcumin can restore leptin-induced tight junction dysfunction in intestinal Caco-2 BBe cells by increasing the expression of tight junction proteins, repairing inflammation-induced impairment of the blood-milk barrier function, enhancing alveolar epithelial integrity under hypoxic conditions, increasing the diabetes-induced blood-retinal barrier capacity, and improving the barrier function of the blood-brain barrier under ischemic conditions

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Because most BPC 157 plasma concentration profiles were below the assay LLQ at all time points, it seems that very little BPC 157 is absorbed into systemic circulation following rectal administration [260]