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Targeting c-Met and EpCAM: a way to overcome drug resistance It has been well established that aberrantly expressed EpCAM has a direct impact on the cell cycle, proliferation, and upregulation of the oncogenic transcription factors c-Myc and cyclin A/E [150]

Finally, how does the cyst(e)ine metabolic network crosstalk with other ferroptosis preventive pathways including the recently identified GCH1/BH4/DHFR axis 7,8

The behavioral alterations that develop in animals injected with LPS or cytokines recapitulate those observed in ill individuals (37, 81)

In addition to the widely used aerobic exercise, an intervention involving large-muscle-mass resistance training has also demonstrated that isometric exercise (30% maximal voluntary isometric contraction, 8 sets1 min contraction) can increase CAT activity and NO bioavailability, consequently eliciting antioxidant responses and lowering blood pressure in 14 hypertensive individuals [173]

Hepatology 77 , 17971835 (2023)

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