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In addition, Jin and Chen (142) found that in diabetic kidney disease, umbelliferone inhibits ferroptosis by activating the nuclear factor E2-related factor 2 (NRF-2)/heme oxygenase-1 (HO-1) pathway, significantly improving kidney damage and reducing ROS generation

GSTM1: GST Enzymes and Glutathione for Environmental Toxins Glutathione S-transferase enzymes attach glutathione to reactive toxins, which renders them water-soluble and ready for excretion

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However, the levels of glutathione can reduce due to age, high blood sugar levels, excessive alcohol use, excessive exercise, exposure to toxins, and illness

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